Royal Air Force Typhoon jets have conducted a mission with French warplanes in a coordinated attack on an subterranean weapons facility in Syria operated by the IS group, as stated by the British defence ministry.
The facility, located using intelligence, was thought to be containing munitions and bombs, the statement said, and was situated in hills just north of the ancient city of Palmyra in the heart of Syria.
"Our aircraft utilized precision-guided Paveway IV munitions to strike a several entry passages providing entry to the depot... preliminary assessments indicate the target was engaged successfully," the MoD said.
There was no sign of any harm to civilians in the strike late on Saturday and each participating jet made a safe return, the MoD added.
The British jets were supported by a Voyager tanker plane.
Daesh - alternatively referred to as Daesh - imposed jihadist rule over large swathes of both Syria and Iraq until 2019.
"This strike shows British leadership, and resolve to stand shoulder to shoulder with our partners, to eliminate any resurgence of the terrorist group and their dangerous and violent ideologies in the Middle East," UK Defence Secretary John Healey remarked.
British military aircraft have conducted patrols over Syria to "forestall any attempted comeback" of the group after its military defeat at the Baghuz confrontation in 2019, the MoD reported.
"I want to thank every member of the UK armed forces who took part in this mission for their expertise and their valour," he added. "They were among numerous UK service members on duty over the festive period. This mission, to remove militants who endanger our way of life, demonstrates how our armed forces are ready to step up, throughout the year, keeping Britain secure domestically and strong abroad."
In December, the American forces carried out what it called a "massive strike" on Daesh sites in the country, after an attack resulted in the deaths of two US servicemembers and a civilian interpreter in the Palmyra area.
The United Nations says IS still has an estimated 5,000 to 7,000 fighters in Iraq and Syria.